PORTLAND — New Relic, long a major Portland technology employer, said June 27 it will conduct its third round of layoffs in as many years and eliminate up to 255 jobs, about 10% of its workforce. The cuts include 155 employees in the U.S. and 57 internationally. Others lost their jobs in prior layoffs that took place in May and June.

In a note to employees, posted on New Relic’s website, CEO Bill Staples said Tuesday’s layoffs follow a review of company operations. That resulted in “difficult decisions around role redundancies, roles or skills not aligned with our strategic priorities, and the performance of individuals, teams, and programs.”

New Relic’s software helps organizations monitor activity on their website and the performance of their online tools. Though the company is based in San Francisco, it put its main engineering office in downtown Portland and employed about 600 here before the pandemic.

Like many tech companies, though, New Relic has shifted to remote and hybrid work, which the company calls “flex first.”

The company has downsized its footprint in the U.S. Bancorp Tower in downtown Portland, also known as “Big Pink,” and it’s not clear how many employees still work in the city. The building’s managers say about 600 people work in the entire tower each day, down from about 3,000 before COVID-19.

New Relic laid off 160 employees in 2021 and another 110 last year.

New Relic didn’t immediately respond to inquiries Tuesday about how the latest job cuts will affect its Portland operation. The company had 2,663 employees at the end of March, according to a financial filing.

New Relic said about half of Tuesday’s layoffs are in “in targeted areas of the organization to address opportunities for consumption business growth going forward.” It said it will hire for other positions and expects to have about as many employees next spring as it did this past March.

The company said it will spend between $18 million and $22 million on termination costs and other expenses related to the restructuring. New Relic said laid-off employees will receive three months’ pay, extended benefits and career placement assistance.

“While the changes today are challenging, especially for those impacted, I am confident in the vision we have for the future, and that today’s change brings it even closer within reach,” Staples wrote.

New Relic has been repositioning its business in the past few years, seeking new market opportunities and a more efficient operating structure. Reuters reported in May that New Relic had been in talks to sell its business to two private equity firms but that talks fell apart because the suitors couldn’t meet the company’s price or arrange loans to finance the purchase.

New Relic reported $926 million in revenue last year, up from $785 million the prior year. It recorded a $179 million loss, compared to a $232 million loss a year earlier.

New Relic shares were up 14 cents Tuesday morning at $65.09. Shares have traded between $47.85 and $86 in the past year.

This article has been updated with additional context from Bill Staples’ note to employees.